Comparative analysis of monoclonal antibody N-glycosylation using stable isotope labelling and UPLC-fluorescence-MS
Literature Information
Publication Date
2015-01-15
DOI
10.1039/C4AN02345E
Impact Factor
4.616
Authors
Silvia Millán Martín, Amy Farrell, Natalia Navas Iglesias, Niaobh McLoughlin, Jonathan Bones
View Original
Abstract
A twoplex method using 12C6 and 13C6 stable isotope analogues (Δmass = 6 Da) of 2-aminobenzoic acid (2-AA) is described for quantitative analysis of N-glycans present on monoclonal antibodies and other glycoproteins using ultra performance liquid chromatography with sequential fluorescence and accurate mass tandem quadrupole time of flight (QToF) mass spectrometric detection.
Related Literature
The synthesis of enantiomerically pure 4-substituted [2.2]paracyclophane derivatives by sulfoxide–metal exchange
Peter B. Hitchcock, Gareth J. Rowlands, Rakesh Parmar
2005-07-25
Communication
DOI: 10.1039/B507394D
Polymer vesicles formed by amphiphilic diblock copolymers containing a thermotropic liquid crystalline polymer block
Jing Yang, Daniel Lévy, Wei Deng, Patrick Keller, Min-Hui Li
2005-08-01
Communication
DOI: 10.1039/B508034G
Evidence of carbon–carbon bond formation on GaAs(100) via Fischer–Tropsch methyleneinsertion reaction mechanism
Neil T. Kemp, Nagindar K. Singh
2005-08-02
Communication
DOI: 10.1039/B506195D
Polydipyrrole- and polydicarbazole-nanorods as new nanosized supports for DNA hybridization
Jean-Paul Lellouche, Senthil Govindaraji, Augustine Joseph, Jyongsik Jang, Kyung Jin Lee
2005-07-14
Communication
DOI: 10.1039/B502483H
Thio[2-(benzoylamino)ethylamino]-β-CD fragment modified gold nanoparticles as recycling extractors for [60]fullerene
Yu Liu, Ying-Wei Yang, Yong Chen
2005-07-21
Communication
DOI: 10.1039/B507650A
Solid-state 87Rb NMR signatures for rubidium cations bound to a G-quadruplex
Ramsey Ida, Gang Wu
2005-08-02
Communication
DOI: 10.1039/B505674H
Shape controlled growth of gold nanoparticles by a solution synthesis
Ying Chen, Xin Gu, Cha-Geng Nie, Zhi-Yuan Jiang, Zhao-Xiong Xie, Chang-Jian Lin
2005-07-13
Communication
DOI: 10.1039/B504911C
Precise synthesis of poly(macromonomer)s containing sugars by repetitive ring-opening metathesis polymerisation
James J. Murphy, Kotohiro Nomura
2005-07-13
Communication
DOI: 10.1039/B506877K
Mechanistic subtleties in the cyclopentannelation of allenolate allyl carbamates: the origin of the center-to-center chirality transfer
Olalla Nieto Faza, Carlos Silva López, Rosana Álvarez, Ángel R. de Lera
2005-07-27
Communication
DOI: 10.1039/B506601H
You might also like
Compound Q&A
How should waste containing N-Methoxy-N-methyl-1,3-thiazole-5-carboxamide (CAS: 898825-89-3) be handled?
Waste containing N-Methoxy-N-methyl-1,3-thiazole-5-carboxamide (CAS: 898825-89-3...
898825-89-3N-Methoxy-N-methyl-1...
Compound Q&A
How should N-(4-Biphenylyl)dibenzo[b,d]furan-4-amine (CAS: 1318338-47-4) be stored?
N-(4-Biphenylyl)dibenzo[b,d]furan-4-amine should be stored in a tightly sealed c...
1318338-47-4N-(4-Biphenylyl)dibe...
Compound Q&A
What is the market or research trend for 3-Acetamido-5-amino-2,4,6-triiodobenzoic acid (CAS: 1713-07-1)?
The market for 3-Acetamido-5-amino-2,4,6-triiodobenzoic acid (CAS: 1713-07-1) is...
1713-07-13-Acetamido-5-amino-...
Compound Q&A
How should Benzyl 2-O-acetyl-3,4,6-tri-O-benzyl-beta-D-galactopyranoside (CAS: 61820-03-9) be stored?
Benzyl 2-O-acetyl-3,4,6-tri-O-benzyl-beta-D-galactopyranoside (CAS: 61820-03-9) ...
61820-03-9Benzyl 2-O-acetyl-3,...
Compound Q&A
What regulatory guidelines apply to 2-Ethylpiperazine dihydrochloride (CAS: 438050-52-3)?
2-Ethylpiperazine dihydrochloride (CAS: 438050-52-3) is regulated under the Glob...
438050-52-32-Ethylpiperazine di...
Compound Q&A
What regulatory guidelines apply to 1,1'-[1,3-Phenylenebis(methylene)]bis(3-methyl-1H-pyrrole-2,5-dione) (CAS: 119462-56-5)?
1,1'-[1,3-Phenylenebis(methylene)]bis(3-methyl-1H-pyrrole-2,5-dione) (CAS: 11946...
119462-56-51,1'-[1,3-Phenyleneb...
Compound Q&A
Are there alternatives to 5-Fluoro-2-(1-pyrrolidinyl)pyridine (CAS: 1287217-79-1) in synthesis?
Several alternatives can be used in the synthesis of 5-Fluoro-2-(1-pyrrolidinyl)...
1287217-79-15-Fluoro-2-(1-pyrrol...
Compound Q&A
What precautions should be taken when handling 1-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxy-3-methoxytetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (CAS: 153631-19-7)?
Proper personal protective equipment (PPE) must be worn when handling this compo...
153631-19-71-((2R,3R,4R,5R)-5-(...
Compound Q&A
What precautions should be taken when handling 6-Bromoimidazo[1,2-a]pyridin-8-amine (CAS: 676371-00-9)?
When handling 6-Bromoimidazo[1,2-a]pyridin-8-amine, it is important to wear appr...
676371-00-96-Bromoimidazo[1,2-a...
Compound Q&A
Are there alternatives to (2S,4R)-4-(4-Nitrobenzyl)pyrrolidine-2-carboxylic acid hydrochloride (CAS: 1049740-22-8) in synthesis?
Alternatives to (2S,4R)-4-(4-Nitrobenzyl)pyrrolidine-2-carboxylic acid hydrochlo...
1049740-22-8(2S,4R)-4-(4-Nitrobe...
Source Journal
Analyst
CiteScore:
7.8
Self-citation Rate:
5.6%
Articles per Year:
653
Analyst publishes analytical and bioanalytical research that reports premier fundamental discoveries and inventions, and the applications of those discoveries, unconfined by traditional discipline barriers.
Recommended Compounds
Recommended Suppliers
Disclaimer
This page provides academic journal information for reference and research purposes only. We are not affiliated with any journal publishers and do not handle publication submissions. For publication-related inquiries, please contact the respective journal publishers directly.
If you notice any inaccuracies in the information displayed, please contact us at support@chemtradehub.com. We will promptly review and address your concerns.