Cascade synthesis of quinazolinones from 2-aminobenzonitriles and aryl bromides via palladium-catalyzed carbonylation reaction

Literature Information

Publication Date 2013-11-07
DOI 10.1039/C3GC42089B
Impact Factor 10.182
Authors

Haoquan Li, Lin He, Helfried Neumann, Matthias Beller, Xiao-Feng Wu


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Abstract

A cascade synthesis of quinazolinones from 2-aminobenzonitriles and aryl bromides through a palladium-catalyzed carbonylation reaction has been developed. Various quinazolinones were produced in moderate to excellent yields. The reactions go through aminocarbonylation of aryl bromides–hydration of nitriles–cyclization sequence. Notably, all the products were isolated by recrystallization.

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