Enantioselective desymmetrisation of citric acid catalysed by the substrate-tolerant petrobactin biosynthetic enzyme AsbA
Literature Information
Daniel Oves-Costales, Lijiang Song, Gregory L. Challis
AsbA catalyses the highly enantioselective desymmetrisation of citric acidvia ATP-dependent condensation with spermidine, as well as the condensation of citric acid with several spermidine analogues and the condensation of the citric acid analogue tricarballylic acid with spermidine, suggesting that it may be a useful biocatalyst for asymmetric synthesis.
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