Highly efficient construction of large molecular cavity using 1,3-alternate tetraoxacalix[2]arene[2]triazine as a platform
Literature Information
Bao-Yong Hou, Qi-Yu Zheng, De-Xian Wang, Zhi-Tang Huang, Mei-Xiang Wang
In the presence of K2CO3 in refluxing THF, dichloro-substituted tetraoxacalix[2]arene[2]triazine, a readily available macrocyclic compound from cyanuric acid chloride and benzyl 1,3-dihydroxybenzoate, underwent highly efficient nucleophilic displacement reactions with bis-nucleophilic reagents of different geometry, length and chirality in a 2+2 fashion to produce large and size-tunable cavity bis-tetraoxacalix[2]arene[2]triazines in good to excellent yields.
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