Fluorescent CXCR4 chemokine receptor antagonists: metal activated binding

Literature Information

Publication Date 2006-12-04
DOI 10.1039/B614557D
Impact Factor 6.222
Authors

Abid Khan, Jon D. Silversides, Leigh Madden, John Greenman, Stephen J. Archibald


View Original

Abstract

The copper(II) complex of a novel rhodamine-azamacrocycle conjugate binds to the CXCR4 chemokine receptor and competes effectively against anti-CXCR4 monoclonal antibodies. The copper macrocycle unit adopts a trans-II configuration in the solid state.

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Front cover

Cover

DOI: 10.1039/C5CP90135A

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