Cyclodextrin-based isolation of Ostwald's metastable polymorphs occurring during crystallization

Literature Information

Publication Date 2005-12-20
DOI 10.1039/B515349B
Impact Factor 6.222
Authors

Yoh Sonoda, Fumitoshi Hirayama, Hidetoshi Arima, Yoshihiro Yamaguchi, Wolfram Saenger, Kaneto Uekama


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Abstract

We describe a novel approach for the selective isolation of Ostwald's intermediate metastable polymorphs occurring during an early stage of crystallization, by utilizing the inclusion complex formed with a cyclic oligosaccharide derivative, 2,6-di-O-methyl-β-cyclodextrin.

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