2-Phenallyl as a versatile protecting group for the asymmetric one-pot three-component synthesis of propargylamines
Literature Information
Nina Gommermann, Paul Knochel
2-Phenallyl was found to be a versatile protecting group of primary amines for the asymmetric one-pot three-component synthesis of propargylamines which leads to enantiomeric excess of up to 96%; it can be easily removed with a palladium(0)-catalyzed allylic substitution using 1,3-dimethylbarbituric acid as a nucleophile.
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