2-Phenallyl as a versatile protecting group for the asymmetric one-pot three-component synthesis of propargylamines

Literature Information

Publication Date 2005-07-26
DOI 10.1039/B507810E
Impact Factor 6.222
Authors

Nina Gommermann, Paul Knochel


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Abstract

2-Phenallyl was found to be a versatile protecting group of primary amines for the asymmetric one-pot three-component synthesis of propargylamines which leads to enantiomeric excess of up to 96%; it can be easily removed with a palladium(0)-catalyzed allylic substitution using 1,3-dimethylbarbituric acid as a nucleophile.

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