Highly regioselective and diastereoselective epoxidation of allylic amines with Oxone

Literature Information

Publication Date 2005-06-09
DOI 10.1039/B503516C
Impact Factor 6.222
Authors

Varinder K. Aggarwal, Guang Yu Fang


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Abstract

Allylic amines (as their protonated ammonium salts) can be epoxidised with high syn diastereoselectivity and regioselectivity at the proximal alkene in substrates with several double bonds using Oxone. The protonated ammonium cation activates the Oxone by hydrogen bonding, thus promoting the oxidation of groups within the vicinity of the complex.

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