Cationic polyhedral oligomeric silsesquioxane (POSS) units as carriers for drug delivery processes

Literature Information

Publication Date 2005-01-10
DOI 10.1039/B416266H
Impact Factor 6.222
Authors

Catherine McCusker, Joseph B. Carroll, Vincent M. Rotello


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Abstract

Quaternary ammonium functionalized polyhedral oligomeric silsesquioxane (OctaAmmonium–POSS®) units, widely employed as additives in ceramic and polymeric systems, possess many attributes which make them attractive as biocompatible drug carriers: nanoscale size, three-dimensional functionality, efficient cellular uptake, low toxicity, and high solubility.

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