Preparation of cyclic alkenylmagnesium reagents via an iodine/magnesium exchange

Literature Information

Publication Date 2004-12-06
DOI 10.1039/B415588B
Impact Factor 6.222
Authors

Hongjun Ren, Arkady Krasovskiy, Paul Knochel


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Abstract

The reaction of various cyclic alkenyl iodides with i-PrMgCl·LiCl produces the corresponding alkenylmagnesium reagents under mild conditions. After reaction with various electrophiles, like allylic halides, disulfides, aldehydes and acid chlorides, the expected products are obtained in 53–91% yield. Remarkably, the mild conditions of the I/Mg-exchange tolerate the presence of sensitive diene functionalities.

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