Luminescent cyclometalated platinum(ii) complexes with amino acidligands for protein binding

Literature Information

Publication Date 2005-01-05
DOI 10.1039/B414936J
Impact Factor 6.222
Authors

Phyllis Kit-Man Siu, Dik-Lung Ma, Chi-Ming Che


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Abstract

Pt(C^N)(phe) (1, C^N = 2-(2′-thienyl)pyridine, phe = phenylalanine) shows a high binding affinity (ca. 106 dm3 mol−1) and selectivity towards human serum albumin (HSA) and such binding is accompanied by an enhancement of photoluminescence at 562 nm; both the protein binding affinity and cytotoxicities of [Pt(C^N)(phe) (1), Pt(C^N)(trp) (2, trp = tryptophan) and Pt(C^N)(gly) (3, gly = glycine)] are affected by the amino acid ligand with 1 having an IC50 of up to 1 μM against a number of carcinoma cell lines.

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