Highly enantioselective dynamic kinetic resolution and desymmetrization processes by cyclocondensation of chiral aminoalcohols with racemic or prochiral δ-oxoacid derivatives

Literature Information

Publication Date 2005-01-20
DOI 10.1039/B413937B
Impact Factor 6.222
Authors

Mercedes Amat, Oriol Bassas, Miquel A. Pericàs, Mireia Pastó, Joan Bosch


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Abstract

Cyclocondensation reactions of aminoalcohols 7 and 8 with racemic or prochiral δ-oxoacid derivatives provide polysubstituted lactams with high enantioselectivity in a process that involves dynamic kinetic resolution and/or desymmetrization of enantiotopic or diastereotopic ester groups.

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