A novel asymmetric route to succinimides and derived compounds: synthesis of the lignan lactone (+)-hinokinin
Literature Information
D. Jonathan Bennett, Paula L. Pickering, Nigel S. Simpkins
A novel approach to chiral succinimides and derived compounds has been developed that involves chiral lithium amide desymmetrisation of an N-ortho-tert-butylphenyl succinimide to generate a putative atropisomeric intermediate enolate, alkylation of which enables access to the lignan lactone (+)-hinokinin.
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