SN2 vs. E2 on quaternary centres: an application to the synthesis of enantiopure β2,2-amino acids
Literature Information
Alberto Avenoza, Jesús H. Busto, Francisco Corzana, Gonzalo Jiménez-Osés, Jesús M. Peregrina
SN2 and E2 competing reactions in cyclic sulfamidates can be modulated by the change of an amide group to an ester group attached to the quaternary carbon activated for the nucleophilic attack, allowing an easy approach to enantiopure α,α-disubstituted β-amino acids.
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