SN2 vs. E2 on quaternary centres: an application to the synthesis of enantiopure β2,2-amino acids

Literature Information

Publication Date 2004-03-16
DOI 10.1039/B400282B
Impact Factor 6.222
Authors

Alberto Avenoza, Jesús H. Busto, Francisco Corzana, Gonzalo Jiménez-Osés, Jesús M. Peregrina


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Abstract

SN2 and E2 competing reactions in cyclic sulfamidates can be modulated by the change of an amide group to an ester group attached to the quaternary carbon activated for the nucleophilic attack, allowing an easy approach to enantiopure α,α-disubstituted β-amino acids.

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