New building blocks for the assembly of sequence selective molecular zippers

Literature Information

Publication Date 2003-06-16
DOI 10.1039/B304041K
Impact Factor 6.222
Authors

Chistopher A. Hunter, Philip S. Jones, Pascale M. N. Tiger, Salvador Tomas


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Abstract

Synthetic H-bonded molecular zippers contain no sequence information that can be used to engineer the selective binding interactions characteristic of biopolymers; reversing the sense of the amide bonds in the two binding partners generates a new orthogonal recognition motif and the mutually complementary binding partners form complexes an order of magnitude more stable than the corresponding mismatch complexes.

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