Gold(iii) porphyrins as a new class of anticancer drugs: cytotoxicity, DNA binding and induction of apoptosis in human cervix epitheloid cancer cells

Literature Information

Publication Date 2003-06-16
DOI 10.1039/B303294A
Impact Factor 6.222
Authors

Chi-Ming Che, Raymond Wai-Yin Sun, Wing-Yiu Yu, Chi-Bun Ko, Nianyong Zhu, Hongzhe Sun


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Abstract

A series of gold(III) tetraarylporphyrins are stable in the presence of glutathione and exert much higher potency than cisplatin in killing human cancer cells, including the drug-resistant variants; the gold-induced cytotoxicity occurs through an apoptotic pathway according to laser confocal microscopy and flow cytometric studies.

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