Distortion of a cellobio-derived isofagomine highlights the potential conformational itinerary of inverting β-glucosidases

Literature Information

Publication Date 2003-03-20
DOI 10.1039/B301592K
Impact Factor 6.222
Authors

Annabelle Varrot, James Macdonald, Robert V. Stick, Gavin Pell, Harry J. Gilbert, Gideon J. Davies


View Original

Abstract

A cellobio-derived isofagomine glycosidase inhibitor (Ki ∼ 400 nM) displays an unusual distorted 2,5B (boat) conformation upon binding to cellobiohydrolase Cel6A from Humicola insolens, highlighting the different conformational itineraries used by various glycosidases, with consequences for the design of therapeutic agents.

Related Literature

How sustainable is CO2 conversion to ethanol? – A life cycle assessment of a new electrocatalytic carbon utilisation process

Daniel Rojas Sánchez, Kaveh Khalilpour, Andrew F. A. Hoadley

2021-10-05 Paper

DOI: 10.1039/D1SE01462E

Rich-phosphorus/nitrogen co-doped carbon for boosting the kinetics of potassium-ion hybrid capacitors

Zhenyu Xie, Daping Qiu, Min Li

2021-11-13 Paper

DOI: 10.1039/D1SE01627J

Controlling the carrier density in niobium oxynitride BaNbO2N via cation doping for efficient photoelectrochemical water splitting under visible light

Takafumi Iwai, Akinobu Nakada, Masanobu Higashi, Hajime Suzuki, Osamu Tomita

2021-10-25 Paper

DOI: 10.1039/D1SE01272J

A mini-review of advanced separator engineering in lithium metal batteries

Huiping Wu, Libao Chen, Yuejiao Chen

2021-09-10 Review Article

DOI: 10.1039/D1SE01152A

Novel single pass biogas-to-diesel process using a Fischer–Tropsch catalyst designed for high conversion

Chelsea L. Tucker, Ankur Bordoloi, Eric van Steen

2021-10-15 Paper

DOI: 10.1039/D1SE01299A

Benefits of active site proximity in Cu@UiO-66 catalysts for efficient upgrading of ethanol to n-butanol

Jian Zhou, Yaohui He, Bing Xue, Yunhui Cheng, Danfeng Zhou, Dong Wang, Yajun He, Weixin Guan, Kegong Fang, Lijun Zhang, Jun Ni, Xiaonian Li

2021-07-29 Paper

DOI: 10.1039/D1SE01002F

High hydrogen release catalytic activity by quasi-MOFs prepared via post-synthetic pore engineering

Minoo Bagheri, Mohammad Yaser Masoomi, Esther Domínguez, Hermenegildo García

2021-07-20 Paper

DOI: 10.1039/D1SE00661D

Contents list

2021-11-09 Front/Back Matter

DOI: 10.1039/D1SE90078A

Self-assembled polypyrrole nanotubes/MoS2 quantum dots for high performance solid state flexible symmetric supercapacitors

Vijeth Hebri, Rabah Boukherroub, Ashokkumar Shankar Pawar, Vandana Molahalli, Devendrappa Hundekal

2021-11-17 Paper

DOI: 10.1039/D1SE01391B

You might also like

Compound Q&A

What precautions should be taken when handling 2-Methyl-2-propanyl 5-amino-2-thiophenecarboxylate (CAS: 1498311-57-1)?

When handling 2-Methyl-2-propanyl 5-amino-2-thiophenecarboxylate (CAS: 1498311-5...

1498311-57-12-Methyl-2-propanyl ...
Compound Q&A

What are the physical and chemical properties of 5-Bromo-1,2-dichloro-3-fluorobenzene (CAS: 1000572-93-9)?

5-Bromo-1,2-dichloro-3-fluorobenzene (CAS: 1000572-93-9) is a crystalline solid ...

1000572-93-95-Bromo-1,2-dichloro...
Compound Q&A

How should (2R)-2-Amino-2-(4-bromophenyl)ethanol (CAS: 354153-64-3) be stored?

(2R)-2-Amino-2-(4-bromophenyl)ethanol (CAS: 354153-64-3) should be stored in a c...

354153-64-3(2R)-2-Amino-2-(4-br...
Compound Q&A

What regulatory guidelines apply to Methyl 4-(aminomethyl)tetrahydro-2H-pyran-4-carboxylate hydrochloride (CAS: 362707-24-2)?

Methyl 4-(aminomethyl)tetrahydro-2H-pyran-4-carboxylate hydrochloride (CAS: 3627...

362707-24-2Methyl 4-(aminomethy...
Compound Q&A

What are the main uses of 1,4-dimethyl-1H-pyrazole-5-sulfonyl chloride (CAS: 1174834-52-6)?

1,4-Dimethyl-1H-pyrazole-5-sulfonyl chloride is primarily used as an intermediat...

1174834-52-61,4-dimethyl-1H-pyra...
Compound Q&A

Is Dinaphtho[1,2-b:2',1'-d]furan (CAS: 239-69-0) safe?

Dinaphtho[1,2-b:2',1'-d]furan is generally safe when handled with appropriate pe...

239-69-0Dinaphtho[1,2-b:2',1...
Compound Q&A

What is the market or research trend for 7-Methyl-7,9-dihydro-1H-purine-2,6,8(3H)-trione (CAS: 612-37-3)?

The market for 7-Methyl-7,9-dihydro-1H-purine-2,6,8(3H)-trione (CAS: 612-37-3) i...

612-37-37-Methyl-7,9-dihydro...
Compound Q&A

What are the physical and chemical properties of 2-(4-Chlorophenyl)malonaldehyde (CAS: 205676-17-1)?

2-(4-Chlorophenyl)malonaldehyde (CAS: 205676-17-1) is a colorless or light yello...

205676-17-12-(4-Chlorophenyl)ma...
Compound Q&A

How is 2-Methylchrysene (CAS: 3351-32-4) typically synthesized?

2-Methylchrysene (CAS: 3351-32-4) is typically synthesized via the reaction of c...

3351-32-42-Methylchrysene
Compound Q&A

Is N-(6-aminopyrimidin-4-yl)acetamide (CAS: 89533-23-3) safe?

N-(6-aminopyrimidin-4-yl)acetamide (CAS: 89533-23-3) is generally considered saf...

89533-23-3N-(6-aminopyrimidin-...

Source Journal

Chemical Communications

Chemical Communications
CiteScore: 8.6
Self-citation Rate: 4.7%
Articles per Year: 2458

ChemComm publishes urgent research which is of outstanding significance and interest to experts in the field, while also appealing to the journal’s broad chemistry readership. Our communication format is ideally suited to short, urgent studies that are of such importance that they require accelerated publication. Our scope covers all topics in chemistry, and research at the interface of chemistry and other disciplines (such as materials science, nanoscience, physics, engineering and biology) where there is a significant novelty in the chemistry aspects. Major topic areas covered include: Analytical Chemistry Catalysis Chemical Biology and medicinal chemistry Computational Chemistry and Machine Learning Energy and sustainable chemistry Environmental Chemistry Green Chemistry Inorganic Chemistry Materials Chemistry Nanoscience Organic Chemistry Physical Chemistry Polymer Chemistry Supramolecular Chemistry

Recommended Suppliers

Disclaimer
This page provides academic journal information for reference and research purposes only. We are not affiliated with any journal publishers and do not handle publication submissions. For publication-related inquiries, please contact the respective journal publishers directly.
If you notice any inaccuracies in the information displayed, please contact us at support@chemtradehub.com. We will promptly review and address your concerns.