Bone mineral: evidence for hydroxy groups by inelastic neutron scattering
Literature Information
Marina G. Taylor, Stewart F. Parker, Kenneth Simkiss, Philip C. H. Mitchell
Inelastic neutron scattering (INS) spectroscopy which is especially sensitive to vibrations of groups with hydrogen has been used to resolve the extent of substitutions at the hydroxy group site in bone. Bone is a complex material consisting of a mineral apatite (Ca5(PO4)3 OH), in an extracellular protein matrix. Many aspects concerning the composition of the mineral are controversial. It has been suggested that there is complete substitution by carbonate at the hydroxy site. Bands assigned to hydroxy vibrations are often not resolved in the infrared and Raman spectra. We show, by INS, that in ox femur bone 40–50% of the hydroxy groups are not substituted. The inelastic neutron scattering experiment opens up new opportunities to monitor changes in bone composition which are important in bone ageing and some pathological conditions.
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Physical Chemistry Chemical Physics

Physical Chemistry Chemical Physics (PCCP) is an international journal co-owned by 19 physical chemistry and physics societies from around the world. This journal publishes original, cutting-edge research in physical chemistry, chemical physics and biophysical chemistry. To be suitable for publication in PCCP, articles must include significant innovation and/or insight into physical chemistry; this is the most important criterion that reviewers and Editors will judge against when evaluating submissions. The journal has a broad scope and welcomes contributions spanning experiment, theory, computation and data science. Topical coverage includes spectroscopy, dynamics, kinetics, statistical mechanics, thermodynamics, electrochemistry, catalysis, surface science, quantum mechanics, quantum computing and machine learning. Interdisciplinary research areas such as polymers and soft matter, materials, nanoscience, energy, surfaces/interfaces, and biophysical chemistry are welcomed if they demonstrate significant innovation and/or insight into physical chemistry. Joined experimental/theoretical studies are particularly appreciated when complementary and based on up-to-date approaches.










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