Compound Q&A

How is Ethyl 2-bromo-4,4,4-trifluorobutanoate (CAS: 367-33-9) typically synthesized?

Answer

Ethyl 2-bromo-4,4,4-trifluorobutanoate
Ethyl 2-bromo-4,4,4-trifluorobutanoate (CAS: 367-33-9) is typically synthesized by reacting 4,4,4-trifluorobutanoic acid with ethyl bromide in the presence of a base such as potassium carbonate, followed by a dehydration step. This method provides good yield and selectivity, with the product being isolated and purified by vacuum distillation.

About

CAS No 367-33-9
English Name Ethyl 2-bromo-4,4,4-trifluorobutanoate
Molecular Formula C6H8BrF3O2
Molecular Weight 249.02599999999995 g/mol
SMILES CCOC(=O)C(CC(F)(F)F)Br
InChIKey POVYUFTVLGOXEE-UHFFFAOYSA-N
Last Updated: 2026-03-16 21:46

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