Dinuclear osmium complexes as mitochondrion-targeting antitumor photothermal agents in vivo

Literature Information

Publication Date 2022-10-18
DOI 10.1039/D2CC05230J
Impact Factor 6.222
Authors

Meng-Fan Wang, Yu-Ang Deng, Qing-Fang Li, Shi-Jie Tang, Rong Yang, Run-Yu Zhao, Fu-Dan Liu, Xiaoxia Ren, Dan Zhang, Feng Gao


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Abstract

Four dinuclear osmium complexes have been constructed for antitumor phototherapy. The most potent Os4 has extremely high photothermal conversion capability under irradiation of an 808 nm low-power laser, targets mitochondria in human melanoma cells without nucleus affinity, and acts as an antitumor photothermal therapy agent in vitro and in vivo.

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