Dinuclear osmium complexes as mitochondrion-targeting antitumor photothermal agents in vivo
Literature Information
Meng-Fan Wang, Yu-Ang Deng, Qing-Fang Li, Shi-Jie Tang, Rong Yang, Run-Yu Zhao, Fu-Dan Liu, Xiaoxia Ren, Dan Zhang, Feng Gao
Four dinuclear osmium complexes have been constructed for antitumor phototherapy. The most potent Os4 has extremely high photothermal conversion capability under irradiation of an 808 nm low-power laser, targets mitochondria in human melanoma cells without nucleus affinity, and acts as an antitumor photothermal therapy agent in vitro and in vivo.
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