Construction of a 4H-pyrido[4,3,2-gh]phenanthridin-5(6H)-one skeleton via a catalyst-free radical cascade addition/cyclization using azo compounds as radical sources

Literature Information

Publication Date 2017-11-22
DOI 10.1039/C7QO00926G
Impact Factor 5.281
Authors

Chen Zhang, Junxia Pi, Shu Chen, Ping Liu, Peipei Sun


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Abstract

A new radical addition/cyano insertion/homolytic aromatic substitution cascade reaction initiated by the thermal homolysis of azo compounds to access polycyclic phenanthridine derivatives has been developed. Under the catalyst and oxidant free conditions, a broad range of N-arylacrylamides are compatible to afford the desired 4H-pyrido[4,3,2-gh]phenanthridin-5(6H)-one derivatives in moderate to high yields.

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