4-Methyl-3-morpholinecarboxylic acid hydrochloride (1:1)
CAS Number:
1240518-90-4
Molecular Formula:
C6H12ClNO3
Cu(i)-Catalyzed amidation/imidation of N-arylglycine ester derivatives via C–N coupling under mild conditions
Literature Information
Publication Date
2017-11-22
DOI
10.1039/C7QO00851A
Impact Factor
5.281
Authors
Ramana V. Daggupati, Chandrasekharam Malapaka
View Original
Abstract
A mild and efficient reaction protocol for the cross-dehydrogenative carbon–nitrogen (CDCN) coupling of N-arylglycine ester derivatives with benzamides, aromatic heterocyclic amides (oxindole, isatins), acyclic and cyclic amides (lactams) and imides (phthalimide, succinimide) has been achieved. The copper-catalyzed C–N coupling reaction exhibits a wide substrate scope with respect to N-arylglycine ester derivatives. The ligand/oxidant free reaction facilitates the direct formation of a C(sp3)–N bond with high atom economy to furnish the corresponding amidated/imidated N-arylglycine ester derivatives in good to excellent yields under open flask conditions.
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Source Journal
Organic Chemistry Frontiers
CiteScore:
7.8
Self-citation Rate:
8.7%
Articles per Year:
724
Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry
Recommended Compounds
1,3(2H,4H)-Isoquinolinedione, 7-amino-4,4-dimethyl-
CAS Number:
14576-22-8
Molecular Formula:
C11H12N2O2
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