6-Bromo-3,4-dihydro-2H-1,4-benzoxazine hydrochloride (1:1)
CAS Number:
1260803-10-8
Molecular Formula:
C8H9BrClNO
l-Phenylalanine potassium catalyzed asymmetric formal [3 + 3] annulation of 2-enoyl-pyridine N-oxides with acetone
Literature Information
Publication Date
2017-10-09
DOI
10.1039/C7QO00796E
Impact Factor
5.281
Authors
Youguo Xu, Sheng Zhang, Lijun Li, Yukang Wang, Zhenggen Zha, Zhiyong Wang
View Original
Abstract
A highly enantioselective formal [3 + 3] annulation of 2-enoyl-pyridine N-oxides with acetone was developed. In this transformation, an amino-acid salt L-phenylalanine potassium proved to be a robust organocatalyst, and the corresponding annulation derivatives can be obtained with moderate to excellent yields (up to 99%) and good to excellent enantioselectivities (up to 94%).
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Source Journal
Organic Chemistry Frontiers
CiteScore:
7.8
Self-citation Rate:
8.7%
Articles per Year:
724
Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry
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