A practical approach for the synthesis of oxindole and isatin derivatives by Pd-catalyzed intramolecular amination
Literature Information
Publication Date
2017-09-05
DOI
10.1039/C7QO00710H
Impact Factor
5.281
Authors
Yubo Pang, Mingyu Guan, Runsheng Zeng, Yingsheng Zhao
View Original
Abstract
Oxindole/isatin-N-acetamide derivatives are a class of important pharmacologically active compounds. Herein, we report a practical protocol for the synthesis of such derivatives based on palladium-catalyzed intramolecular amination. Various functional groups are tolerated, and the corresponding products are obtained in moderate to good yields, highlighting the potential synthetic utility of this method.
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Source Journal
Organic Chemistry Frontiers
CiteScore:
7.8
Self-citation Rate:
8.7%
Articles per Year:
724
Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry
Recommended Compounds
6-Bromo-3,4-dihydro-2H-1,4-benzoxazine hydrochloride (1:1)
CAS Number:
1260803-10-8
Molecular Formula:
C8H9BrClNO
2,2-dideuterio-2-(3,4,5,6-tetradeuterio-2-pyridyl)acetic acid;hydrochloride
CAS Number:
1329799-67-8
Molecular Formula:
C7H2ClD6NO2
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