Gold-catalyzed diversified synthesis of 3-aminosugar analogues of digitoxin and digoxin
Literature Information
Publication Date
2017-09-06
DOI
10.1039/C7QO00648A
Impact Factor
5.281
Authors
Jing Zeng, Guangfei Sun, Ruobin Wang, Shuxin Zhang, Shuang Teng, Zhiwen Liao, Lingkui Meng
View Original
Abstract
A diversified synthesis of 3-aminosugar analogues of digitoxin and digoxin with potent anticancer activities was explored. The synthesis was based on a highly efficient gold-catalyzed glycosylation reaction with alkynylbenzoate 3-aminoglycosides as glycosyl donors. According to this strategy, a small library containing digitoxin and digoxin analogues with various 3-aminosugar scaffolds was successfully constructed.
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Source Journal
Organic Chemistry Frontiers
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