Synthetic strategies towards mycolactone A/B, an exotoxin secreted by Mycobacterium ulcerans
Literature Information
Publication Date
2017-08-28
DOI
10.1039/C7QO00608J
Impact Factor
5.281
Authors
Sarah Saint-Auret, Hajer Abdelkafi, Didier Le Nouen, Philippe Bisseret, Nicolas Blanchard
View Original
Abstract
Mycolactone A/B, a complex polyketidic macrolide secreted by Mycobacterium ulcerans, has been synthesized using catalytic and/or asymmetric reactions. Several palladium-catalyzed reactions were investigated for forging key σ-bonds as well as a particularly challenging hydroboration reaction of a functionalized and sterically demanding 1,1-disubstituted exo-alkene. The full account of these investigations is discussed.
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Organic Chemistry Frontiers
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