Copper(ii) catalyzed domino synthesis of quinoline derivatives from arylamines and alkynes
Literature Information
Publication Date
2017-07-04
DOI
10.1039/C7QO00333A
Impact Factor
5.281
Authors
Huimin Dai, Chun-Xiao Li, Chao Yu, Zihao Wang, Hong Yan, Changsheng Lu
View Original
Abstract
The Cu(OAc)2·H2O catalyzed domino reaction of primary arylamines and electron-deficient terminal alkynes was developed at room temperature. It provides a convenient access to a variety of 2,4-disubstituted quinolines in good to excellent yields without protection from moisture or air. Control experiments suggest that the reaction might be initiated from alkyne homocoupling, followed by copper catalyzed hydroamination and cyclization.
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Source Journal
Organic Chemistry Frontiers
CiteScore:
7.8
Self-citation Rate:
8.7%
Articles per Year:
724
Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry
Recommended Compounds
2,2-dideuterio-2-(3,4,5,6-tetradeuterio-2-pyridyl)acetic acid;hydrochloride
CAS Number:
1329799-67-8
Molecular Formula:
C7H2ClD6NO2
6-Bromo-3,4-dihydro-2H-1,4-benzoxazine hydrochloride (1:1)
CAS Number:
1260803-10-8
Molecular Formula:
C8H9BrClNO
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