Iodine-catalyzed cascade annulation of alkynes with sodium arylsulfinates: assembly of 3-sulfenylcoumarin and 3-sulfenylquinolinone derivatives

Literature Information

Publication Date 2017-05-25
DOI 10.1039/C7QO00326A
Impact Factor 5.281
Authors

Yanni An, Jianxiao Li, Shaorong Yang, Zhongzhi Zhu, Huanfeng Jiang


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Abstract

An efficient and versatile iodine-catalyzed electrophilic cyclization has been achieved to afford functionalized 3-sulfenylcoumarin and 3-sulfenylquinolinone derivatives in moderate to good yields from readily available alkynes with sodium arylsulfinates. Moreover, broad substrate scope, excellent functional group compatibility, and high-value products make this protocol practical and attractive, offering potential applications in organic synthesis and medicinal chemistry.

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Organic Chemistry Frontiers

Organic Chemistry Frontiers
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Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry

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