A direct metal-free C2–H functionalization of quinoline N-oxides: a highly selective amination and alkylation strategy towards 2-substituted quinolines
Literature Information
Publication Date
2017-05-11
DOI
10.1039/C7QO00311K
Impact Factor
5.281
Authors
Wen-Zhu Bi, Kai Sun, Chen Qu, Xiao-Lan Chen, Shao-Hua Zhu, Xu Li, Hai-Tao Wu, Li-Kun Duan
View Original
Abstract
An efficient one-pot methodology for C2-selective amination and alkylation of quinoline N-oxides towards 2-substituted quinolines was developed, via the reaction of various quinoline N-oxides with ammonia, a large variety of primary and secondary amines, as well as active methylene compounds in the presence of diethyl H-phosphonate and K2CO3 under metal free conditions at room temperature.
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Source Journal
Organic Chemistry Frontiers
CiteScore:
7.8
Self-citation Rate:
8.7%
Articles per Year:
724
Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry
Recommended Compounds
6-Bromo-3,4-dihydro-2H-1,4-benzoxazine hydrochloride (1:1)
CAS Number:
1260803-10-8
Molecular Formula:
C8H9BrClNO
![S-[2,3-Bis(palmitoyloxy)propyl]-N-[(9H-fluoren-9-ylmethoxy)(hydroxy)methylene]cysteine structure](https://static.chemtradehub.com/structs/210/210532-98-2-f6a7.webp "S-[2,3-Bis(palmitoyloxy)propyl]-N-[(9H-fluoren-9-ylmethoxy)(hydroxy)methylene]cysteine structure")
S-[2,3-Bis(palmitoyloxy)propyl]-N-[(9H-fluoren-9-ylmethoxy)(hydroxy)methylene]cysteine
CAS Number:
210532-98-2
Molecular Formula:
C53H83NO8S
6-CHLORO-2,3-DIOXO-1,2,3,4-TETRAHYDROQUINOXALINE, 97
CAS Number:
169-14-2
Molecular Formula:
C8H5ClN2O2
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