Pd-Catalyzed thiophene directed regioselective functionalization of arenes: a direct approach to multiply-substituted benzyl amines

Literature Information

Publication Date 2017-04-28
DOI 10.1039/C7QO00236J
Impact Factor 5.281
Authors

Jundie Hu, Guobao Li, Zhi-Bin Huang, Jingyu Zhang, Da-Qing Shi, Yingsheng Zhao


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Abstract

The first example of employing thiophene as the coordination center to assist C–H functionalization via a palladium catalyst has been described. The synthetically challenging penta-substituted benzylamines with five different functional groups could be easily achieved by taking advantage of transitive oxalyl amide/thiophene-directed C–H functionalization, which highlights its versatility in the construction of multiply-substituted arenes. The penta-substituted benzylamine displays its potential nature as a hole-transporting material.

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