The structural diversity of C-rich DNA aggregates: unusual self-assembly of beetle-like nanostructures
Literature Information
A. D. Protopopova, V. B. Tsvetkov, A. M. Varizhuk, N. A. Barinov, V. V. Podgorsky, D. V. Klinov, G. E. Pozmogova
We studied the ability of oligonucleotides CnT25 (n = 2, 5, 7, 9, 12, 25) to form an intermolecular i-motif using circular dichroism, ultra-violet spectroscopy, nuclear magnetic resonance, high-resolution atomic force microscopy, high-performance liquid chromatography, and molecular dynamics simulations. The arrangement of single-stranded oligonucleotides in multimer i-motifs was very unusual: C-tracts of different oligonucleotides followed each other consecutively in order to fold into a closed intermolecular i-motif core with minimal loops (one cytidine in a loop spanning over a minor groove, three cytidines in a loop over a major groove); intact T-tracts protruded from predefined loci allowing visualization of beetle-like nanostructures by atomic force microscopy. The same structures were formed from analogous biotinylated oligonucleotides demonstrating one of the potential applications of such structures as carriers of multiple functional groups. Our findings open up possibilities for the rational design of pH-sensitive DNA aggregates and evaluation of the efficiency of their assembly.
Recommended Journals

Saudi Pharmaceutical Journal

Russian Journal of Applied Chemistry

Chemistry Education Research and Practice

Current Opinion in Colloid & Interface Science

Russian Journal of General Chemistry

Russian Journal of Bioorganic Chemistry

Organic Process Research & Development

Journal of Saudi Chemical Society

Journal of Peptide Science

Current Opinion in Solid State & Materials Science
Related Literature
Electrical conductivity of reverse micelles in supercritical carbon dioxide
Christian Blattner, Jürgen Bittner, Georg Schmeer, Werner Kunz
DOI: 10.1039/B109085B
Is xenon an “ennobled” alkane?
Eduardo J. M. Filipe, Lino M. B. Dias, Jorge C. G. Calado, Clare McCabe, George Jackson
DOI: 10.1039/B109165B
Mechanistic studies on the bromate–1,4-cyclohexanedione–ferroin oscillatory system
István Szalai, Krisztina Kurin-Csörgei, Miklós Orbán
DOI: 10.1039/B109388F
Raman structural study of thymine and its 2′-deoxy-ribosyl derivatives in solid state, aqueous solution and when adsorbed on silver nanoparticles
Laura Rivas, Santiago Sánchez-Cortés, José V. García-Ramos
DOI: 10.1039/B110564G
Dynamic channels of a porous coordination polymer responding to external stimuli
DOI: 10.1039/B110899A
Transformation of diamond nanoparticles into carbon onions under electron irradiation
V. V. Roddatis, V. L. Kuznetsov, Yu. V. Butenko, D. S. Su, R. Schlögl
DOI: 10.1039/B110487J
Structuring of poly(DADMAC) chains in aqueous media: a comparison between bulk and free-standing film measurements
Regine v. Klitzing, Branko Kolarić, Werner Jaeger, Astrid Brandt
DOI: 10.1039/B106929M
NMR studies of the molecular dynamics of tert-butyl chloride confined in the mesoporous molecular sieve MCM-41
Lidia Wasyluk, Barbara Peplinska, Stefan Jurga
DOI: 10.1039/B200634K
Influence of building block aromaticity in the determination of electronic properties of five-membered heterocyclic oligomers
David Delaere, Minh Tho Nguyen, Luc G. Vanquickenborne
DOI: 10.1039/B109008A
New fluorescent probes for visual proteins Part I. Photophysical properties of 3-(oxo)propenyl-4′-(N,N-dimethylamino)benzoate
Vladislav Papper, Vladimir Kharlanov, Wolfgang Rettig
DOI: 10.1039/B111681A
You might also like
What precautions should be taken when handling 4-Methyl-6-(trifluoromethyl)quinoline (CAS: 40716-16-3)?
When handling 4-Methyl-6-(trifluoromethyl)quinoline (CAS: 40716-16-3), safety go...
What is 4-(3,5-Difluorophenyl)aniline (CAS: 405058-00-6)?
4-(3,5-Difluorophenyl)aniline is an aromatic organic compound with the CAS numbe...
How is 5-{[4-(Trifluoromethyl)phenyl]sulfanyl}-1,2,3-thiadiazole-4-carboxylic acid (CAS: 338982-07-3) typically synthesized?
5-{[4-(Trifluoromethyl)phenyl]sulfanyl}-1,2,3-thiadiazole-4-carboxylic acid can ...
What is the market or research trend for 4-Benzylaniline hydrochloride (CAS: 6317-57-3)?
The market for 4-Benzylaniline hydrochloride (CAS: 6317-57-3) is steadily growin...
Is [3-(Diethylsulfamoyl)phenyl]boronic acid (CAS: 871329-58-7) safe?
[3-(Diethylsulfamoyl)phenyl]boronic acid is generally considered safe when handl...
What are the main uses of 3-Bromo-2,5-dimethoxyaniline (CAS: 115929-62-9)?
3-Bromo-2,5-dimethoxyaniline is mainly used in the pharmaceutical and chemical i...
What regulatory guidelines apply to N-Methyl-1-(5-methyl-1H-indol-3-yl)methanamine (CAS: 915922-67-7)?
N-Methyl-1-(5-methyl-1H-indol-3-yl)methanamine (CAS: 915922-67-7) is subject to ...
What industries use Carbamic acid, N-[(5S)-5,6-diamino-6-oxohexyl]-, 1,1-dimethylethyl ester (CAS: 24828-96-4)?
This compound is primarily used in the pharmaceutical industry for the synthesis...
How should 2-Methyl-2-propanyl [(1S,3R)-3-aminocyclohexyl]carbamate (CAS: 1298101-47-9) be stored?
2-Methyl-2-propanyl [(1S,3R)-3-aminocyclohexyl]carbamate (CAS: 1298101-47-9) sho...
What industries use Ethyl 2-bromo-4,4,4-trifluorobutanoate (CAS: 367-33-9)?
Ethyl 2-bromo-4,4,4-trifluorobutanoate (CAS: 367-33-9) is utilized in the pharma...
Source Journal
Physical Chemistry Chemical Physics

Physical Chemistry Chemical Physics (PCCP) is an international journal co-owned by 19 physical chemistry and physics societies from around the world. This journal publishes original, cutting-edge research in physical chemistry, chemical physics and biophysical chemistry. To be suitable for publication in PCCP, articles must include significant innovation and/or insight into physical chemistry; this is the most important criterion that reviewers and Editors will judge against when evaluating submissions. The journal has a broad scope and welcomes contributions spanning experiment, theory, computation and data science. Topical coverage includes spectroscopy, dynamics, kinetics, statistical mechanics, thermodynamics, electrochemistry, catalysis, surface science, quantum mechanics, quantum computing and machine learning. Interdisciplinary research areas such as polymers and soft matter, materials, nanoscience, energy, surfaces/interfaces, and biophysical chemistry are welcomed if they demonstrate significant innovation and/or insight into physical chemistry. Joined experimental/theoretical studies are particularly appreciated when complementary and based on up-to-date approaches.


![Methyl 3-({2'-[(E)-(hydroxyhydrazono)methyl]-4-biphenylyl}methyl)-2-oxo-2,3-dihydro-1H-benzimidazole-4-carboxylate structure Methyl 3-({2'-[(E)-(hydroxyhydrazono)methyl]-4-biphenylyl}methyl)-2-oxo-2,3-dihydro-1H-benzimidazole-4-carboxylate structure](https://static.chemtradehub.com/structs/149/1499167-72-4-034a.webp)

![[3-(2,6-Dichlorophenyl)-5-isopropyl-1,2-oxazol-4-yl]methanol structure [3-(2,6-Dichlorophenyl)-5-isopropyl-1,2-oxazol-4-yl]methanol structure](https://static.chemtradehub.com/structs/278/278597-30-1-5c79.webp)