Hyperbranched PEG-based multi-NHS polymer and bioconjugation with BSA
Literature Information
Publication Date
2017-01-04
DOI
10.1039/C6PY01719C
Impact Factor
5.582
Authors
Sigen A, Qian Xu, Dezhong Zhou, Yongsheng Gao, Jeddah Marie Vasquez, Udo Greiser, Wenguang Liu
View Original
Abstract
Star-shaped poly(ethylene glycol)-N-hydroxysuccinimide (star-PEG-NHS) has shown great promise in a variety of biomedical applications owing to its non-toxicity, innate non-immunogenic properties and versatile, multifunctional end groups. However, its complex and sophisticated synthetic methods, as well as high costs, have significantly impeded its wide application. Here, we report the design and synthesis of a hyperbranched PEG-based polymer with multiple NHS functional groups (>12). The hyperbranched PEG-based multi-NHS polymer can react easily with a protein (bovine serum albumin, BSA) to form a PEG-protein hydrogel that displays great potential for biomedical applications.
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Source Journal
Polymer Chemistry
CiteScore:
8.6
Self-citation Rate:
7.3%
Articles per Year:
457
Polymer Chemistry welcomes submissions in all areas of polymer science that have a strong focus on macromolecular chemistry. Manuscripts may cover a broad range of fields, yet no direct application focus is required.
Recommended Compounds
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S-[2,3-Bis(palmitoyloxy)propyl]-N-[(9H-fluoren-9-ylmethoxy)(hydroxy)methylene]cysteine
CAS Number:
210532-98-2
Molecular Formula:
C53H83NO8S
6-CHLORO-2,3-DIOXO-1,2,3,4-TETRAHYDROQUINOXALINE, 97
CAS Number:
169-14-2
Molecular Formula:
C8H5ClN2O2
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(3R,5R)-1-[(Benzyloxy)carbonyl]-5-methyl-3-piperidinecarboxylic acid
CAS Number:
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Molecular Formula:
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