An ultrasensitive electrochemical immunosensor based on the synergistic effect of quaternary Cu2SnZnS4 NCs and cyclodextrin-functionalized graphene

Literature Information

Publication Date 2017-01-17
DOI 10.1039/C6AN02538B
Impact Factor 4.616
Authors

Lei Liu, Yihe Zhang, Ruifeng Du, Jinhong Li, Xuelian Yu


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Abstract

In this study, highly monodispersed Cu2SnZnS4 NCs with a quasi-spherical structure were prepared to construct a sandwich-type electrochemical immunosensor for alpha-fetoprotein detection. Quaternary Cu2SnZnS4 NCs as novel biomimetic catalysts show an efficient intrinsic peroxidase-like activity for H2O2 reduction. This excellent catalytic activity is ascribed to the higher electroconductivity than those of the binary Cu2S and ternary Cu2SnS3 NCs. Moreover, β-cyclodextrin-functionalized graphene sheets are used as substrate materials that can capture large amounts of primary antibodies due to host–guest interaction and high surface area. Under the optimized conditions, the electrochemical immunosensor exhibites a wide working range from 0.5 pg mL−1 to 10 ng mL−1 and a detection limit of 0.16 pg mL−1 at a signal-to-noise ratio of 3. Good sensitivity, reproducibility, and stability demonstrate its potential application in clinical diagnostics.

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