A reduction-responsive polypeptide nanogel encapsulating NIR photosensitizer for imaging guided photodynamic therapy
Literature Information
Publication Date
2015-11-25
DOI
10.1039/C5PY01629K
Impact Factor
5.582
Authors
Titao Jing, Liyi Fu, Le Liu, Lifeng Yan
View Original
Abstract
A new bromine substituted near infrared (NIR) cyanine Br2-IR808 has been synthesized, and the heavy atom effect makes it an efficient photosensitizer with NIR fluorescence properties, and it can be used as both a photosensitizer and a fluorescent dye synchronously. An intelligent reduction-sensitive polypeptide nanogel has also been synthesized, and it worked as the nano-carrier for the Br2-IR808 dye. The as-prepared NIR nanogel showed imaging guided PDT properties for in vitro studies, and the reduction-induced disassembly of the nanogel could promote the delivery of the hydrophobic cyanine dye inside the cell, and it also enhances the efficiency of the photosensitizer release, which makes the nanogel potential for application in NIR theranosis of cancer. In addition, only 2 μM photosensitizer Br2-IR808 is required for efficient PDT here while 30 μM IR808 is required solely as reported.
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Source Journal
Polymer Chemistry
CiteScore:
8.6
Self-citation Rate:
7.3%
Articles per Year:
457
Polymer Chemistry welcomes submissions in all areas of polymer science that have a strong focus on macromolecular chemistry. Manuscripts may cover a broad range of fields, yet no direct application focus is required.
Recommended Compounds
6-CHLORO-2,3-DIOXO-1,2,3,4-TETRAHYDROQUINOXALINE, 97
CAS Number:
169-14-2
Molecular Formula:
C8H5ClN2O2
2,2-dideuterio-2-(3,4,5,6-tetradeuterio-2-pyridyl)acetic acid;hydrochloride
CAS Number:
1329799-67-8
Molecular Formula:
C7H2ClD6NO2
![S-[2,3-Bis(palmitoyloxy)propyl]-N-[(9H-fluoren-9-ylmethoxy)(hydroxy)methylene]cysteine structure](https://static.chemtradehub.com/structs/210/210532-98-2-f6a7.webp "S-[2,3-Bis(palmitoyloxy)propyl]-N-[(9H-fluoren-9-ylmethoxy)(hydroxy)methylene]cysteine structure")
S-[2,3-Bis(palmitoyloxy)propyl]-N-[(9H-fluoren-9-ylmethoxy)(hydroxy)methylene]cysteine
CAS Number:
210532-98-2
Molecular Formula:
C53H83NO8S
![1-[(4-Methylphenyl)sulfonyl]-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine-5-carbonitrile structure](https://static.chemtradehub.com/structs/143/1434747-57-5-fc0d.webp "1-[(4-Methylphenyl)sulfonyl]-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine-5-carbonitrile structure")
1-[(4-Methylphenyl)sulfonyl]-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine-5-carbonitrile
CAS Number:
1434747-57-5
Molecular Formula:
C21H22BN3O4S
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