1,3(2H,4H)-Isoquinolinedione, 7-amino-4,4-dimethyl-
CAS Number:
14576-22-8
Molecular Formula:
C11H12N2O2
Facile production of nanoaggregates with tuneable morphologies from thermoresponsive P(DEGMA-co-HPMA)
Literature Information
Publication Date
2015-11-16
DOI
10.1039/C5PY01467K
Impact Factor
5.582
Authors
Nghia P. Truong, Michael R. Whittaker, John F. Quinn
View Original
Abstract
Thermoresponsive polymers are used to produce nanoparticles or nanoaggregates for a wide range of applications such as nanomedicine. However, low-toxicity, thermoresponsive polymers such as methacrylate polymers with short oligo(ethylene glycol) side chains are not readily applicable to the synthesis of nanoaggregates with both spherical and nonspherical morphologies. Here we report the synthesis of a low-toxicity, thermoresponsive copolymer, P(DEGMA-co-HPMA), and describe its application in the RAFT-mediated emulsion polymerization of styrene as a means to produce nanoparticles with tuneable morphology (sphere, cylinder, vesicle and lamella). These nanoaggregates offer considerable potential as a novel platform for the next generation of nanotherapeutics with improved efficacy.
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Source Journal
Polymer Chemistry
CiteScore:
8.6
Self-citation Rate:
7.3%
Articles per Year:
457
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