![6-Bromo-3-ethyl-3H-imidazo[4,5-b]pyridine structure](https://static.chemtradehub.com/structs/103/1033202-59-3-2a8f.webp "6-Bromo-3-ethyl-3H-imidazo[4,5-b]pyridine structure")
Triplex DNA logic gate based upon switching on/off their structure by Ag+/cysteine
Literature Information
Publication Date
2015-08-25
DOI
10.1039/C5AN01371B
Impact Factor
4.616
Authors
Houya Zhu, Aiping Xin, Yubin Li, Liansheng Ling
View Original
Abstract
The formation of intramolecular triplex DNA can be regulated by Ag+ and Cys (cysteine), which switch off/on the fluorescence of the oligonucleotides, 5′-TAMRA-TTC TCT TCC TCT TCC TTC TGA CGA CAG TTG ACT CTT CCT TCT CCT TCT CTT-BHQ-2-3′ (Oligo 1) and 3′-GAA GGA AGA GGA AGA GAA-5′ (Oligo 2). Based on this principle, sensors for Ag+ and Cys are developed. The sensor for Ag+ has a linear range of 2.5 nM–40 nM and a detection limit of 1.8 nM, whereas the sensor for Cys has a linear range of 10.0 nM–120.0 nM and a detection limit of 8.2 nM. Furthermore, the fluorescence is reversible with the alternate addition of Ag+ and Cys. We constructed a DNA logic gate using Ag+ and Cys as the input, and the fluorescence intensity as the output. The DNA logic gate is simple; moreover, it has a fast response and good reversibility.
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Analyst
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Self-citation Rate:
5.6%
Articles per Year:
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Analyst publishes analytical and bioanalytical research that reports premier fundamental discoveries and inventions, and the applications of those discoveries, unconfined by traditional discipline barriers.
Recommended Compounds
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(4aR,5S,6R,8aS)-5-[2-(3-Furyl)ethyl]-8a-(hydroxymethyl)-5,6-dimethyl-3,4,4a,5,6,7,8,8a-octahydro-1-naphthalenecarboxylic acid
CAS Number:
18411-75-1
Molecular Formula:
C20H28O4
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2,4-Dichloro-6-isopropyl-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one
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Molecular Formula:
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