Heavy atom quenched coumarin probes for sensitive and selective detection of biothiols in living cells

Literature Information

Publication Date 2015-05-01
DOI 10.1039/C5AN00549C
Impact Factor 4.616
Authors

Yuzhuo Ji, Qingqing Jin, Qingxiao Tong, Xinjing Tang


View Original

Abstract

A series of turn-on fluorescent probes with halogen acetyl amide at the 3-position of coumarin derivatives were synthesized. Fluorescence of these probes was efficiently quenched by heavy halogen atoms (Br and I, not Cl), which could be successfully used for selective detection of biothiols with the sensitivity of Cys > GSH > Hcy and much higher than thiol containing proteins. These represent the smallest fluorescence quenchers in designing fluorescent probes for detecting both endogenous and exogenous biothiols in living cells.

Related Literature

MoS2 nanosheets as an effective fluorescence quencher for DNA methyltransferase activity detection

Huimin Deng, Xinjian Yang, Zhiqiang Gao

2015-03-02 Paper

DOI: 10.1039/C4AN02133A

Nanoporous copper oxide ribbon assembly of free-standing nanoneedles as biosensors for glucose

Shaodong Sun, Yuexia Sun, Anran Chen, Xiaozhe Zhang, Zhimao Yang

2015-05-20 Paper

DOI: 10.1039/C5AN00609K

The application of FAIMS gas analysis in medical diagnostics

J. A. Covington, M. P. van. der Schee, A. S. L. Edge, B. Boyle, R. P. Arasaradnam

2015-07-17 Minireview

DOI: 10.1039/C5AN00868A

A near-infrared fluorescent probe for the selective detection of HNO in living cells and in vivo

Ping Liu, Xiaotong Jing, Changjun Lv

2015-05-14 Paper

DOI: 10.1039/C5AN00759C

A sensitive biosensor with a DNAzyme for lead(ii) detection based on fluorescence turn-on

Yang Guo, Junting Li, Xiaoqian Zhang, Yanli Tang

2015-05-15 Paper

DOI: 10.1039/C5AN00677E

The real-time in vivo electrochemical measurement of nitric oxide and carbon monoxide release upon direct epidural electrical stimulation of the rat neocortex

Sarah S. Park, Minyoung Hong, Yejin Ha, Gil-Ja Jhon, Youngmi Lee

2015-02-25 Paper

DOI: 10.1039/C5AN00122F

Nanopipette delivery: influence of surface charge

Wenqing Shi, Niya Sa, Rahul Thakar, Lane A. Baker

2014-07-30 Paper

DOI: 10.1039/C4AN01073F

Correlation of the impedance and effective electrode area of doped PEDOT modified electrodes for brain–machine interfaces

Alexander R. Harris, Paul J. Molino, Graeme M. Clark, Antonio G. Paolini, Gordon G. Wallace

2015-03-09 Paper

DOI: 10.1039/C4AN02362E

You might also like

Compound Q&A

What precautions should be taken when handling 4-Methyl-6-(trifluoromethyl)quinoline (CAS: 40716-16-3)?

When handling 4-Methyl-6-(trifluoromethyl)quinoline (CAS: 40716-16-3), safety go...

40716-16-34-Methyl-6-(trifluor...
Compound Q&A

What is 4-(3,5-Difluorophenyl)aniline (CAS: 405058-00-6)?

4-(3,5-Difluorophenyl)aniline is an aromatic organic compound with the CAS numbe...

405058-00-64-(3,5-Difluoropheny...
Compound Q&A

How is 5-{[4-(Trifluoromethyl)phenyl]sulfanyl}-1,2,3-thiadiazole-4-carboxylic acid (CAS: 338982-07-3) typically synthesized?

5-{[4-(Trifluoromethyl)phenyl]sulfanyl}-1,2,3-thiadiazole-4-carboxylic acid can ...

338982-07-35-{[4-(Trifluorometh...
Compound Q&A

What is the market or research trend for 4-Benzylaniline hydrochloride (CAS: 6317-57-3)?

The market for 4-Benzylaniline hydrochloride (CAS: 6317-57-3) is steadily growin...

6317-57-34-Benzylaniline hydr...
Compound Q&A

Is [3-(Diethylsulfamoyl)phenyl]boronic acid (CAS: 871329-58-7) safe?

[3-(Diethylsulfamoyl)phenyl]boronic acid is generally considered safe when handl...

871329-58-7[3-(Diethylsulfamoyl...
Compound Q&A

What are the main uses of 3-Bromo-2,5-dimethoxyaniline (CAS: 115929-62-9)?

3-Bromo-2,5-dimethoxyaniline is mainly used in the pharmaceutical and chemical i...

115929-62-93-Bromo-2,5-dimethox...
Compound Q&A

What regulatory guidelines apply to N-Methyl-1-(5-methyl-1H-indol-3-yl)methanamine (CAS: 915922-67-7)?

N-Methyl-1-(5-methyl-1H-indol-3-yl)methanamine (CAS: 915922-67-7) is subject to ...

915922-67-7N-Methyl-1-(5-methyl...
Compound Q&A

What industries use Carbamic acid, N-[(5S)-5,6-diamino-6-oxohexyl]-, 1,1-dimethylethyl ester (CAS: 24828-96-4)?

This compound is primarily used in the pharmaceutical industry for the synthesis...

24828-96-4Carbamic acid, N-[(5...
Compound Q&A

How should 2-Methyl-2-propanyl [(1S,3R)-3-aminocyclohexyl]carbamate (CAS: 1298101-47-9) be stored?

2-Methyl-2-propanyl [(1S,3R)-3-aminocyclohexyl]carbamate (CAS: 1298101-47-9) sho...

1298101-47-92-Methyl-2-propanyl ...
Compound Q&A

What industries use Ethyl 2-bromo-4,4,4-trifluorobutanoate (CAS: 367-33-9)?

Ethyl 2-bromo-4,4,4-trifluorobutanoate (CAS: 367-33-9) is utilized in the pharma...

367-33-9Ethyl 2-bromo-4,4,4-...

Source Journal

Analyst

Analyst
CiteScore: 7.8
Self-citation Rate: 5.6%
Articles per Year: 653

Analyst publishes analytical and bioanalytical research that reports premier fundamental discoveries and inventions, and the applications of those discoveries, unconfined by traditional discipline barriers.

Recommended Compounds

Recommended Suppliers

Disclaimer
This page provides academic journal information for reference and research purposes only. We are not affiliated with any journal publishers and do not handle publication submissions. For publication-related inquiries, please contact the respective journal publishers directly.
If you notice any inaccuracies in the information displayed, please contact us at support@chemtradehub.com. We will promptly review and address your concerns.