![6,7-Dihydro-5H-pyrrolo[1,2-a]imidazole-6-carboxylic acid structure](https://static.chemtradehub.com/structs/136/1369160-12-2-6524.webp "6,7-Dihydro-5H-pyrrolo[1,2-a]imidazole-6-carboxylic acid structure")
6,7-Dihydro-5H-pyrrolo[1,2-a]imidazole-6-carboxylic acid
CAS Number:
1369160-12-2
Molecular Formula:
C7H8N2O2
Nanopore analysis of amyloid fibrils formed by lysozyme aggregation
Literature Information
Publication Date
2015-05-12
DOI
10.1039/C5AN00530B
Impact Factor
4.616
Authors
Nikolay Martyushenko, Nicholas A. W. Bell, Robin D. Lamboll, Ulrich F. Keyser
View Original
Abstract
The measurement of single particle size distributions of amyloid fibrils is crucial for determining mechanisms of growth and toxicity. Nanopore sensing is an attractive solution for this problem since it gives information on aggregates’ shapes with relatively high throughput for a single particle technology. In this paper we study the translocation of lysozyme fibrils through quartz glass nanopores. We demonstrate that, under appropriate salt and pH conditions, lysozyme fibrils translocate through bare quartz nanopores without causing significant clogging. This enables us to measure statistics on tens of thousands of translocations of lysozyme fibrils with the same nanopore and track their development over a time course of aggregation spanning 24 h. Analysis of our events shows that the statistics are consistent with a simple bulk conductivity model for the passage of rods with a fixed cross sectional area through a conical glass nanopore.
Related Literature
Oxygen-induced degradation of the electronic properties of thin-layer InSe
Xin Wei, Chaofang Dong, Aoni Xu, Xiaogang Li, Digby D. Macdonald
2017-12-19
Paper
DOI: 10.1039/C7CP07446H
A synergic approach of X-ray powder diffraction and Raman spectroscopy for crystal structure determination of 2,3-thienoimide capped oligothiophenes
C. Cappuccino, T. Salzillo, E. Venuti, A. Giunchi, R. G. Della Valle, A. Brillante, C. Bettini, M. Melucci, L. Maini
2018-01-02
Paper
DOI: 10.1039/C7CP06679A
Photodissociation dynamics of bromoiodomethane from the first and second absorption bands. A combined velocity map and slice imaging study
David V. Chicharro, Eduardo Navarro, Luis Rubio-Lago, Luis Bañares
2018-01-03
Paper
DOI: 10.1039/C7CP07077B
Corrosion protection of Al(111) by 8-hydroxyquinoline: a comprehensive DFT study
Marie-Laure Bonnet, Corinne Lacaze-Dufaure, Hao Tang, Nadine Pébère
2018-07-26
Paper
DOI: 10.1039/C8CP03312A
Resolving the halogen vs. hydrogen bonding dichotomy in solutions: intermolecular complexes of trihalomethanes with halide and pseudohalide anions
Brandon Watson, Olivia Grounds, William Borley, Sergiy V. Rosokha
2018-08-07
Paper
DOI: 10.1039/C8CP03505A
Single Pd atomic catalyst on Mo2CO2 monolayer (MXene): unusual activity for CO oxidation by trimolecular Eley–Rideal mechanism
Cheng Cheng, Xilin Zhang, Mingyang Wang, Shiyan Wang
2018-01-04
Paper
DOI: 10.1039/C7CP07161B
Bias-scanning based tunable LSPR sensor
Yifei Tao, Kai Guo, Fei Shen, Hongping Zhou, Yongxuan Sun, Renbin Zhang, Qingfeng Zhou, Zhiping Yin
2017-12-14
Communication
DOI: 10.1039/C7CP07565K
Improved multivariate analysis for fast and selective monitoring of structural dynamics by in situ X-ray powder diffraction‡
Pietro Guccione, Marco Milanesio, Benny Danilo Belviso, Rocco Caliandro
2017-10-26
Paper
DOI: 10.1039/C7CP06326A
Lithium permeation within lithium niobate multilayers with ultrathin chromium, silicon and carbon spacer layers
Erwin Hüger, Lars Dörrer, Rattikorn Yimnirun, Jaru Jutimoosik, Jochen Stahn, Amitesh Paul
2018-09-03
Paper
DOI: 10.1039/C8CP03345E
Nanoparticle-induced ion-sensitive reduction in decane–water interfacial tension
Boyao Wen, Chengzhen Sun, Bofeng Bai
2018-08-08
Paper
DOI: 10.1039/C8CP04041A
You might also like
Compound Q&A
What precautions should be taken when handling 4-Methyl-6-(trifluoromethyl)quinoline (CAS: 40716-16-3)?
When handling 4-Methyl-6-(trifluoromethyl)quinoline (CAS: 40716-16-3), safety go...
40716-16-34-Methyl-6-(trifluor...
Compound Q&A
What is 4-(3,5-Difluorophenyl)aniline (CAS: 405058-00-6)?
4-(3,5-Difluorophenyl)aniline is an aromatic organic compound with the CAS numbe...
405058-00-64-(3,5-Difluoropheny...
Compound Q&A
How is 5-{[4-(Trifluoromethyl)phenyl]sulfanyl}-1,2,3-thiadiazole-4-carboxylic acid (CAS: 338982-07-3) typically synthesized?
5-{[4-(Trifluoromethyl)phenyl]sulfanyl}-1,2,3-thiadiazole-4-carboxylic acid can ...
338982-07-35-{[4-(Trifluorometh...
Compound Q&A
What is the market or research trend for 4-Benzylaniline hydrochloride (CAS: 6317-57-3)?
The market for 4-Benzylaniline hydrochloride (CAS: 6317-57-3) is steadily growin...
6317-57-34-Benzylaniline hydr...
Compound Q&A
Is [3-(Diethylsulfamoyl)phenyl]boronic acid (CAS: 871329-58-7) safe?
[3-(Diethylsulfamoyl)phenyl]boronic acid is generally considered safe when handl...
871329-58-7[3-(Diethylsulfamoyl...
Compound Q&A
What are the main uses of 3-Bromo-2,5-dimethoxyaniline (CAS: 115929-62-9)?
3-Bromo-2,5-dimethoxyaniline is mainly used in the pharmaceutical and chemical i...
115929-62-93-Bromo-2,5-dimethox...
Compound Q&A
What regulatory guidelines apply to N-Methyl-1-(5-methyl-1H-indol-3-yl)methanamine (CAS: 915922-67-7)?
N-Methyl-1-(5-methyl-1H-indol-3-yl)methanamine (CAS: 915922-67-7) is subject to ...
915922-67-7N-Methyl-1-(5-methyl...
Compound Q&A
What industries use Carbamic acid, N-[(5S)-5,6-diamino-6-oxohexyl]-, 1,1-dimethylethyl ester (CAS: 24828-96-4)?
This compound is primarily used in the pharmaceutical industry for the synthesis...
24828-96-4Carbamic acid, N-[(5...
Compound Q&A
How should 2-Methyl-2-propanyl [(1S,3R)-3-aminocyclohexyl]carbamate (CAS: 1298101-47-9) be stored?
2-Methyl-2-propanyl [(1S,3R)-3-aminocyclohexyl]carbamate (CAS: 1298101-47-9) sho...
1298101-47-92-Methyl-2-propanyl ...
Compound Q&A
What industries use Ethyl 2-bromo-4,4,4-trifluorobutanoate (CAS: 367-33-9)?
Ethyl 2-bromo-4,4,4-trifluorobutanoate (CAS: 367-33-9) is utilized in the pharma...
367-33-9Ethyl 2-bromo-4,4,4-...
Source Journal
Analyst
CiteScore:
7.8
Self-citation Rate:
5.6%
Articles per Year:
653
Analyst publishes analytical and bioanalytical research that reports premier fundamental discoveries and inventions, and the applications of those discoveries, unconfined by traditional discipline barriers.
Recommended Compounds
Recommended Suppliers
Disclaimer
This page provides academic journal information for reference and research purposes only. We are not affiliated with any journal publishers and do not handle publication submissions. For publication-related inquiries, please contact the respective journal publishers directly.
If you notice any inaccuracies in the information displayed, please contact us at support@chemtradehub.com. We will promptly review and address your concerns.