Innovative well-defined primary amine-based polyacrylates for plasmid DNA complexation

Literature Information

Publication Date 2014-06-16
DOI 10.1039/C4PY00585F
Impact Factor 5.582
Authors

Hien The Ho, Sagrario Pascual, Véronique Montembault, Nathalie Casse, Laurent Fontaine


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Abstract

Well-defined quaternized poly(2-aminoethyl acrylate)s (qPAEAs) have been synthesized by RAFT polymerization of N-(tert-butoxycarbonyl)aminoethyl acrylate (t-BocAEA) followed by t-Boc group deprotection. The ability of qPAEAs to act as potential “smart” DNA carriers has been shown by plasmid DNA/qPAEA complexation and qPAEA degradation in water at 37 °C without any trigger.

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