Fluorescent polymer-based post-translational differentiation and subtyping of breast cancer cells
Literature Information
Publication Date
2012-10-04
DOI
10.1039/C2AN35877H
Impact Factor
4.616
Authors
Michael D. Scott, Rinku Dutta, Manas K. Haldar, Anil Wagh, Thomas R. Gustad, Benedict Law, Daniel L. Friesner, Sanku Mallik
View Original
Abstract
Herein, we report the application of synthesized fluorescent, water soluble polymers for post-translational subtyping and differentiation of breast cancer cells in vitro. The fluorescence emission spectra from these polymers were modulated differently in the presence of conditioned cell culture media from various breast cancer cells. These polymers differentiate at a post-translation level possibly due to their ability to interact with extracellular enzymes that are over-expressed in cancerous conditions.
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