A potential role for protein tyrosine phosphatase inhibition by a RuIII–edta complex (edta = ethylenediaminetetraacetate) in its biological activity
Literature Information
Publication Date
2008-05-28
DOI
10.1039/B803261K
Impact Factor
6.222
Authors
Debabrata Chatterjee, Anannya Mitra, Aviva Levina, Peter A. Lay
View Original
Abstract
[RuIII(edta)(OH2/OH)]1−/2− (edta = ethylenediaminetetraacetate) inhibits protein tyrosine phosphatase (PTP) at physiological pH values in a mechanism that involves binding of the Cys residue of the catalytic domain of the enzyme and similar interactions may be important in the anti-cancer properties of the active forms of many Ru pro-drugs.
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Source Journal
Chemical Communications
CiteScore:
8.6
Self-citation Rate:
4.7%
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2458
ChemComm publishes urgent research which is of outstanding significance and interest to experts in the field, while also appealing to the journal’s broad chemistry readership. Our communication format is ideally suited to short, urgent studies that are of such importance that they require accelerated publication. Our scope covers all topics in chemistry, and research at the interface of chemistry and other disciplines (such as materials science, nanoscience, physics, engineering and biology) where there is a significant novelty in the chemistry aspects. Major topic areas covered include: Analytical Chemistry Catalysis Chemical Biology and medicinal chemistry Computational Chemistry and Machine Learning Energy and sustainable chemistry Environmental Chemistry Green Chemistry Inorganic Chemistry Materials Chemistry Nanoscience Organic Chemistry Physical Chemistry Polymer Chemistry Supramolecular Chemistry
Recommended Compounds
cis-3-Amino-1-(trifluoromethyl)cyclobutanol hydrochloride (1:1)
CAS Number:
1408075-16-0
Molecular Formula:
C5H9ClF3NO
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