Synthesis of the DEF-bis-spiroacetal of spirastrellolide A exploiting a double asymmetric dihydroxylation/spiroacetalisation strategy
Literature Information
Ian Paterson, Edward A. Anderson, Stephen M. Dalby, Jong Ho Lim, Philip Maltas, Christian Moessner
An efficient synthesis of the C26–C40 tricyclic [5,6,6]-bis-spiroacetal segment of the marine macrolide spirastrellolide A has been developed, exploiting a novel double Sharpless asymmetric dihydroxylation/spiroacetalisation sequence.
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