A short water-soluble self-assembling peptide forms amyloid-like fibrils
Literature Information
Publication Date
2006-08-30
DOI
10.1039/B607657B
Impact Factor
6.222
Authors
Sudipta Ray, Apurba K. Das, Michael G. B. Drew, Arindam Banerjee
View Original
Abstract
A water-soluble tripeptide Val–Ile–Ala (VIA) 1, bearing sequence identity with the C-terminal portion of the Alzheimer Aβ-peptide (Aβ40–42), self-assembles, in crystalline form, to produce an intermolecularly hydrogen bonded supramolecular β-sheet structure which self-associates to form straight, unbranched nanofibrils exhibiting amyloid-like behavior; in contrast, the synthetic tripeptide Ala–Val–Ile (AVI) 2 self-assembles to produce a β-sheet structure that forms branched nanofibrils which do not show any characteristic features of amyloid-like fibrils.
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Source Journal
Chemical Communications
CiteScore:
8.6
Self-citation Rate:
4.7%
Articles per Year:
2458
ChemComm publishes urgent research which is of outstanding significance and interest to experts in the field, while also appealing to the journal’s broad chemistry readership. Our communication format is ideally suited to short, urgent studies that are of such importance that they require accelerated publication. Our scope covers all topics in chemistry, and research at the interface of chemistry and other disciplines (such as materials science, nanoscience, physics, engineering and biology) where there is a significant novelty in the chemistry aspects. Major topic areas covered include: Analytical Chemistry Catalysis Chemical Biology and medicinal chemistry Computational Chemistry and Machine Learning Energy and sustainable chemistry Environmental Chemistry Green Chemistry Inorganic Chemistry Materials Chemistry Nanoscience Organic Chemistry Physical Chemistry Polymer Chemistry Supramolecular Chemistry
Recommended Compounds
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N-[2-(4-Hydroxyphenoxy)-4-nitrophenyl]methanesulfonamide
CAS Number:
109032-22-6
Molecular Formula:
C13H12N2O6S
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S-[2,3-Bis(palmitoyloxy)propyl]-N-[(9H-fluoren-9-ylmethoxy)(hydroxy)methylene]cysteine
CAS Number:
210532-98-2
Molecular Formula:
C53H83NO8S
2,2-dideuterio-2-(3,4,5,6-tetradeuterio-2-pyridyl)acetic acid;hydrochloride
CAS Number:
1329799-67-8
Molecular Formula:
C7H2ClD6NO2
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