Investigations on substituent and solvent effects on solvolysis reactions Part IX. The influence of polar substituents on the imidazole catalyzed hydrolysis of 2,4-dinitrophenyl acetates in water

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DOI 10.1039/A901004A
Impact Factor 3.676
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Abstract

The imidazole catalyzed hydrolysis of polar substituted 2,4-dinitrophenyl acetates in water has been investigated at different temperatures. The observed rates correspond to the bimolecular nucleophilic addition of the imidazole at the carboxylic carbon atom followed by a very fast hydrolysis of the N-acetylimidazole in water. The influence of polar substituents in the acid moiety of the ester molecule on the hydrolysis reaction can be described by an electrostatic dipole–dipole interaction in the same way as the neutral hydrolysis of polar substituted ethyl acetates.

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Physical Chemistry Chemical Physics

Physical Chemistry Chemical Physics
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